Chemistry Lead (Induced Proximity), London, Lausanne

Description

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. Join our expanding Exploratory Sciences team, focused on tackling proteins which are critical for disease biology, but have been traditionally considered intractable. We are a small, multidisciplinary team within the Drug Design and Medical Research function at Isomorphic Labs. We work at the interface of machine learning, chemical biology and drug discovery to apply our platform to some of the toughest problems in drug discovery, and we collaborate closely with multiple teams across Isomorphic Labs.

We are expanding and investing in our multidisciplinary Induced Proximity team within Exploratory Sciences, looking to recruit a number of talented scientists to drive projects towards the clinic. This role is for a Chemistry Lead, specialising in induced proximity.

Responsibilities

• Deliver the development and application of a state-of-the-art induced proximity design platform.
• Apply our platform in novel ways, and critically drive portfolio projects towards the clinic.
• Design and execute on bold strategies to tackle problems that are currently considered impossible.
• Collaborate with world leading AI/ML and Drug Design Platform teams to deliver scientific expertise and strategic direction.
• Utilise internal AI/ML models to solve challenging drug discovery problems.
• Collaborate both internally and with third party organizations, interacting within multidisciplinary teams to support data-driven delivery of high quality scientific solutions.
• Represent the company externally, interacting with existing and prospective collaborators and contract research organisations (CROs).
• Prepare detailed scientific proposals and reports to support new and ongoing programs.
• Embrace and champion our culture of inclusion and continuous professional development.

Qualifications

• Essential:
  • PhD in Chemistry, or a related technical field, or equivalent experience.
  • 3+ years’ professional experience in a Chemistry role, either operating within a biotech or pharma setting, or within a Post Doc position.
  • Practical experience in the design and synthesis of chemical inducers of proximity/molecular glues, ideally with experience of applying these skills to active drug discovery projects.
  • Broad knowledge of current chemical biology techniques.
  • Experience of coding in Python, or a willingness to learn in-role.
  • A genuine passion and enthusiasm for applying AI/ML to drug design and how this can transform the field.
  • Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a cross-functional, collaborative team environment.
  • A track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.
• Nice to have:
  • Experience working with or managing activities at contract research organisations (CROs).
  • Experience of contributing to structure-based drug design (SBDD) problems.
  • Experience of applying ML methods to Drug Discovery problems.
  • Track record of authorship of relevant scientific manuscripts.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in).