DMPK Lead (PBPK Specialist), London, Lausanne

Description

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

About the DMPK and Quantitative Pharmacology team

The DMPK and Quantitative Pharmacology team, part of the Preclinical Development group, accelerates the delivery of high quality drug candidates by developing innovative and creative AI-first solutions.

Your impact

At Isomorphic Labs, DMPK Leads drive the DMPK strategy of drug discovery and development projects to deliver high quality clinical candidates whilst using and contributing to the optimisation of state-of-the-art computational and AI ADME models. As part of the Drug Design and Medical Research team and through close collaboration with the Technology teams, you will support the business alongside world leading AI/ML Drug Design Platform teams. You will collaborate to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design projects. You use your expertise in PBPK modelling to make data integration a powerful tool to accelerate drug design and preclinical development.

Responsibilities

• Define Iso’s PBPK strategy leading to fit for purpose models that drive drug design and accelerate accelerate preclinical development.
• Design and implement stage-appropriate development DMPK strategies with AI-first approach, integrate the quantitative pharmacology and overall project strategies.
• Design mechanistic experiments to support project progression in a data-driven manner.
• Integrate DMPK, PD and toxicological data to extract decision-making information, including dose and safety window predictions.
• Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads.
• Optimise molecule design and formulation based on physico-chemistry and biotransformation knowledge in collaboration with Chemistry Leads.
• Maintain knowledge of state-of-the-art technologies and methods to increase confidence in human PK prediction.
• Author DMPK sections of regulatory documents.
• Embrace and champion a culture of inclusion and continuous professional development.
• Optimise the use of Iso’s datasets to address fundamental DMPK questions and advance the field.

Skills and qualifications

Essential:

• PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject.
• 5+ years’ professional as a DMPK Lead, solving DMPK-related problems in preclinical development with a track record of working collaboratively to deliver regulatory-ready FIH packages.
• Practical experience in setting up automated PBPK workflows.
• Practical experience in using PBPK to support preclinical development.
• Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development, including authoring and reviewing regulatory documents, ideally in oncology.
• Advanced knowledge of PK and PKPD modelling.
• Experience of partnering closely with Preclinical and Clinical teams.

Nice to have:

• Experience with biologics, peptides and other new modalities.
• Good understanding of machine learning techniques.
• Familiarity with Python and KNIME.

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

• Thoughtful
• Brave
• Determined
• Together

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.